Hello, and |

I'm a medical student at Indiana University passionate about psychiatry, preventive medicine, and contributing to accessible, sustainable innovation in healthcare.

roles medical student, legislative advocate, design/innovation lecturer; former founder and biomedical engineer
interests writing, drawing, podcasting (Impatient Optimists on Spotify), videography
email
Johns Hopkins Bayview Medical Center OR
Johns Hopkins Bayview Medical Center · Photo: Keith Weller
Sabin Karki at Hopkins Bayview OR
Experimenting with surgical staplers and clip appliers at Hopkins Bayview · Photo: Keith Weller

About

I'm passionate about psychiatry, neuroscience, and the engineering of better mental healthcare. My research interests include interventional psychiatry, addiction medicine, and innovative, scalable approaches to mental health.

At IU's Neural Systems Laboratory, I'm building quantitative models of alcohol tolerance and cognitive-behavioral effects, work foundational to understanding addiction as a disease of individual variation. Previously at Stanford, I studied Body Dysmorphic Disorder and psychiatric comorbidities in surgical populations, and I've published on opioid prescribing patterns with direct relevance to addiction psychiatry.

While in college, I started Theramate with a Johns Hopkins psychiatrist to create a mobile app to help providers monitor patients with mood and substance use disorders and reduce readmissions for dual-diagnosis patients. It was my first real lesson in what psychiatry needs: not just better drugs, but better systems.

I also co-founded and exited surgical instrument startup Benegraft (acquired by Osteopore, 2021), served on the venture investment diligence team at Boomerang Ventures with a psychiatry/neurology focus, and teach design thinking as faculty at Purdue's BME program.

What's New
Neural Systems Laboratory, IU School of Medicine2025–
Impatient Optimists, Spotify & YouTube Show2025–
Boomerang Ventures, VC Fund Team – Psychiatry/Neurology Focus2023–
Purdue University BME, Design & Innovation Faculty2024–
Education
M.D. (in progress), Indiana University School of MedicineExp. 2027
M.S. Cellular & Integrative Physiology, IU School of Medicine2021
B.S. Biomedical Engineering, Johns Hopkins University2020

Clinical & Translational Research

Alcohol Pharmacokinetics and Cognitive-Behavioral Effects Addiction

2025 – present
Student Researcher, Neural Systems Laboratory, IU SOM · Advisor: Dr. Martin Plawecki, MD, PhD

Investigating how alcohol exposure drives acute tolerance through integrated pharmacokinetic data, subjective response measures, and neuroadaptation models. Building quantitative mathematical models of individual and group differences in alcohol sensitivity by drinking phenotype.

Body Dysmorphic Disorder, Psychiatric Risk Stratification & Surgical Outcomes Psychiatry

2023 – 2025
Visiting Scholar, Stanford University School of Medicine · Advisor: Dr. Sam P. Most, MD

Studied the relationship between BDD screening, patient expectations, and cosmetic outcomes. Contributed to research on psychological risk stratification and psychiatric comorbidities in surgical populations. Co-authored publication in Aesthetic Surgery Journal.

Chronic Opioid Prescribing Patterns After Head & Neck Cancer Surgery Addiction

2023 – 2024
Student Researcher, IU SOM Dept. of Otolaryngology · Advisor: Dr. Janice Farlow, MD, PhD

Analyzed persistent opioid use following surgery, identifying behavioral and clinical risk factors for chronic opioid exposure with direct relevance to addiction psychiatry. Published systematic review in Otolaryngology–Head and Neck Surgery.

FDA-Approved Home-Based tDCS for Major Depressive Disorder Interventional

2025 – 2026
INSIGHT IU Medical Research Journal, Jan. 2026 · NNDC Best Practices Scholar, Mayo Clinic

Clinical efficacy and implementation considerations of transcranial direct current stimulation for MDD — reviewing evidence for a novel, scalable approach to treatment-resistant depression.

Publications & Patents

Journal Publications
Clinical Efficacy and Implementation Considerations of FDA-Approved Home-Based tDCS for Major Depressive Disorder Psychiatry Karki S. — INSIGHT IU Medical Research Journal, Jan. 2026
Rhinoplasty Outcomes in Patients with Symptoms of Body Dysmorphia Psychiatry Losorelli S, Kimura KS, Wei EX, Karki S, Most SP. — Aesthetic Surgery Journal, Mar. 2024
Unveiling Prescribing Patterns: Systematic Review of Chronic Opioid Prescriptions After Head and Neck Cancer Surgeries Addiction Karki S, Stephanian BA, et al. — Otolaryngology–Head and Neck Surgery, 2024
Role of AI and Machine Learning in Facial Aesthetic Surgery: A Systematic Review Stephanian B, Karki S, et al. — Facial Plastic Surgery & Aesthetic Medicine, vol. 26, no. 6, 2024
The State of Global Surgery Assessment and Data Collection Tools: A Scoping Review Gianaris K, Stephanian B, Karki S, et al. — World Journal of Surgery, Oct. 2024
Listening Closely Karki S. — INSIGHT IU Medicine and Humanities Journal, Apr. 2023 · Narrative medicine
A Cartilage Dicing Tool for Rapid Preparation of Rhinoplasty Grafts Stephanian BA, Karki S, et al. — Journal of Medical Devices, 14(4), 2020
Patents
Corneal Sensory Testing Device and Methods of Using the Same Borschel GH, Stephanian B, Karki S — U.S. Provisional Patent No. 29/944,659, filed May 2024
Mechanism for Dicing Cartilage Byrne PJ, Stephanian BA, Karki S, et al. — International Patent No. WO2021178955A1, 2021

Startups & Translational Work

Theramate

2017 – 2019
Co-Founder & Technical Lead · Johns Hopkins Hexcite Fellow

Founded with a Johns Hopkins psychiatrist to build EMR-integrated software allowing providers to monitor patients with mood and substance use disorders, reducing readmissions for dual-diagnosis patients. Only undergraduate admitted to the Hopkins School of Medicine Health Technology Accelerator.

Benegraft, LLC Acquired 2021

2018 – 2021
CEO & Co-Founder · Acquired by Osteopore

Spun out of Johns Hopkins BME. Led a team of seven to commercialize the first surgical instrument to simplify cartilage graft preparation for rhinoplasty. Raised seed funding, authored IP claims, and led acquisition by Osteopore — debuted at AAO-HNSF 2022.

Boomerang Ventures

2023 – present
Investment Fund Team · Psychiatry/Neurology Focus · Advisor: Dr. Eric Beier, MD, MBA

Conducting due diligence and stakeholder interviews for seed-to-Series A investments in connected healthcare. Focus: digital therapeutics, neurology, VR in pain management, and mental health technology.

Auris Health Acquired by J&J

2019
Clinical Engineering Intern

Performed root cause analysis on FDA MAUDE-flagged issues in Auris's telesurgical platform. Devised first software workflows for clinical data retrieval and analysis using Qubole on Amazon S3.

Impatient Optimists

2025 – present
Writer & Creator · Spotify & YouTube

Stories about innovators reshaping medicine and leadership. Episodes include Reality Distortion: AI Slop and the Modern Battle for Truth and How a Doctor Brought the da Vinci System to the OR. Listen on Spotify →

Legislative Advocacy

State Delegate and Medical Student Representative, Indiana State Medical Association. Authored or co-authored the following resolutions and legislation:

Passed into Law
Supporting Rural Ambulance Services in Indiana ✓ Indiana HB 1385 (2024)
Adopted Resolutions
Ethical Incorporation of AI Tools in Health Care2023
Transparency of Patient Health Data Usage and Sharing2023
Mental Health & Equity
Promoting Mental Health Initiatives For Refugees In Indiana2024
Advocating for All-Payer Coverage for Survivors of Intimate Partner Violence2023
Supporting Comprehensive Coverage of Chronic Weight Management Medications2024
Supporting Access to Menstrual Health Products in Indiana Schools2024
Access & Innovation
Encouraging Incentivized Health Monitoring for Preventive Care2024
Promoting Transparency and Accountability in Healthcare Billing2024
Supporting Exemption from Sales Tax for Essential Family Care Items2024

Writing & Media

Narrative Medicine · INSIGHT IU Medicine and Humanities Journal, 2023

Listening Closely

A first-person account of volunteering in the Johns Hopkins pediatric ED — on the gap between clinical care and community need.

Long-form Essay · Impatient Optimists, July 2025

State of the Self-Driving Car: Where Are They Taking Us?

A deep technical and societal exploration of autonomous vehicles — from sensor physics to urban planning implications.

Invited Address · Health Humanities Consortium 2026 International Conference

The Physician Founder: Reengineering Empathy into Biomedical Technology Innovation

Indianapolis, April 2026.

Podcast Interview · The Physician Pharmacist Podcast

Interview with Nathan Garland

Available on YouTube and Spotify.

Fellowships & Awards

National Network of Depression Centers Best Practices Scholarship, Mayo Clinic2025
NASA Doctoral Research Fellowship, Indiana Space Grant Consortium2024
Inclusive Excellence Grant, IU School of Medicine2024
Cancer Screening Community Action Grant, IU SOM2024
Emerging Leader Award, IU School of Medicine2023
1st Place, University of Minnesota National Medical Device Design Competition2020
1st Place, Johns Hopkins University Business Plan Competition2020
Finalist, National Collegiate Inventors Competition2020
1st Place, $20,000 Johns Hopkins Ten by Twenty Idea Lab Challenge2017
Johns Hopkins Medicine Hexcite Tech Accelerator Fellow2017
NSF I-CORPS DC Research Grant2019
Mr. Science of Indiana, Office of Governor Michael Pence2016
National Merit Scholar · Valedictorian, Terre Haute South Vigo High School2016
Finalist, Intel International Science & Engineering Fair2016

Library

Here are some books and other resources I love.

Entrepreneurship

  • Paul Yock & Stefanos Zenios — Biodesign
  • Paul Graham — EssaysRead →
  • Burfield & Harrison — Regulatory Hacking: A Playbook for Startups
  • Uri Levine — Fall in Love with the Problem, Not the Solution
  • Steve Blank's SiteVisit →
  • NVCA Model Legal DocumentsVisit →
  • Cooley GO (Startup Legal)Visit →

Blogs & Resource Libraries

Healthcare Policy

  • Eichhorn & Hutchinson — Healing American Healthcare

Finance & Investing

  • Warren Buffett — Annual Letters to BRK Shareholders (The Essays of Warren Buffett, Lawrence Cunningham)
  • Charlie Munger — Poor Charlie's Almanack
  • Peter Lynch — One Up on Wall Street

Personal Philosophy

  • Hans Rosling — Factfulness
  • David Christian — Origin Story: A Big History of Everything
  • Gov. JB Pritzker, Northwestern Commencement — Cruelty is a Coward's Tool